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The miR-17–92 cluster gene is primarily transcripted into an 800 bp long polycistron and is subsequently processed into 6 individual miRNAs (miR-17, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a). 12 The miR-17–92 cluster is broadly expressed at every stage of development, with the mature miRNAs detectable in almost all tissues at
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17 ( A : S XXVIII , Foerster : Aiol et Mir . 8. 468 , adm . t . v . 1794. Med den senare upplöser Bimreglering miRrors microRNA 17 ∼ 92 klusteruttryck i endotelceller in vivo inklusive miR-17 - 92-klustermedlemmar miR-17-5p och miR-92a-3p, som MicroRNA-17-92-klustret främjar proliferationen och kemokinproduktionen av keratinocyter: implikation för patogenesen av psoriasis.
Gene family The role of miR-17~92 in human disease is not limited to cancer.
13 Nov 2019 A computationally predicted shared target of the miR-17-92 miRNAs is the pro- apoptotic BCL-2 family protein BIM, central to life-death decisions
08-508 20 _ki lt pådemiiomiln Micoach-mir aa inmm'uhm'äm myndigheter. till lältzw 311 man (Apoteksbolaget 17), 92 anställda inom administrationen (Apoteksbolaget Syrmir 3 300. Syslesjøen 5 246.
"Rött kött och resistent stärkelse har motsatta effekter på kolorektal cancer främjande miRNA, MIR-17-92 kluster", säger Karen J. Humphreys, PhD,
Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed in human cancers and has been shown to promote several aspects of oncogenic transformation, including evasion of apoptosis.
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14, 15 Together these three miRNA clusters represent a combined
MiR-17-92 cluster promotes HCC cell growths in vitro. Human HCC cells (Huh-7 and Sk-Hep-1) were infected with miR-17-92 cluster lentivirus and miRNA scrambled control lentivirus, respectively.
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As discussed, the mir-17-92 cluster has been proposed to have a functional relationship with Patched signalling. An abnormal functioning of which can induce the GNP tumours typical of Medullablastoma. This hypothesis was arrived at by taking miRNA expression profiles of GNP-like tumour cells from mouse mutants.
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17 92 0:3582. SyeuskTvflttmedelsindustri. A:'B., I,. Svensen H, Frejg. 46A. Mirski A, Kungsholmsg. 19. 'I'houren G, Klarabergsg.
Mirhagen, Mattias (S). Edenborg, Love (MP).